A novel approach to tracer-kinetic modeling of (macromolecular) multi-bolus DCE-MRI data, applied in a murine tumor model
نویسندگان
چکیده
model Igor Jacobs, Gustav Strijkers, Henk Keizer, Henk Janssen, Klaas Nicolay, and Matthias Schabel Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, Center for Imaging Research and Education, Eindhoven, Netherlands, SyMO-Chem BV, Eindhoven, Netherlands, Advanced Imaging Research Center, Oregon Health and Science University, Portland, Oregon, United States
منابع مشابه
Direct estimation of tracer-kinetic parameter maps from highly undersampled brain dynamic contrast enhanced MRI.
PURPOSE The purpose of this work was to develop and evaluate a T1 -weighted dynamic contrast enhanced (DCE) MRI methodology where tracer-kinetic (TK) parameter maps are directly estimated from undersampled (k,t)-space data. THEORY AND METHODS The proposed reconstruction involves solving a nonlinear least squares optimization problem that includes explicit use of a full forward model to conver...
متن کاملAutomatic Alignment of Renal DCE-MRI Image Series for Improvement of Quantitative Tracer Kinetic Studies
Tracer kinetic modeling with dynamic contrast enhanced MRI (DCE-MRI) and the quantification of the kinetic parameters are active fields of research which have the potential to improve the measurement of renal function. However, the strong coronal motion of the kidney in the time series inhibits an accurate assessment of the kinetic parameters. Automatic motion correction is challenging due to t...
متن کاملIn vitro validation of permeability-surface area product derived by distributed parameter model with DCE-MRI
Introduction: Dynamic contrast enhanced MRI (DCE-MRI) with tracer kinetic modeling has been proposed as a biomarker of tumor angiogenesis assessment in humans. Several tracer kinetic models, distributed parameter model (DP), St. Lawrence and Lee model (ATH), and conventional compartmental model (CC), have been proposed to calculate permeability-surface area product (PS). It was found that PS co...
متن کاملPET and MRI-guided focused ultrasound surgery for hypoxic-tissue ablation combined with radiotherapy in solid tumors
Background: The rationale was to develop an ablation approach to destroy regions of tumor resistant to radiation and thus reduce the time required for whole tumor ablation, while improving overall tumor control after radiotherapy. Materials and Methods: The system is composed of a micro positron emission tomography (mPET), 7T magnetic resonance imaging (MRI), and a customized MRI-compatible foc...
متن کاملEffect of Bias in Contrast Agent Concentration Measurement on Estimated Pharmacokinetic Parameters in Brain Dynamic Contrast-Enhanced Magnetic Resonance Imaging Studies
Introduction: Pharmacokinetic (PK) modeling of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely applied in tumor diagnosis and treatment evaluation. Precision analysis of the estimated PK parameters is essential when they are used as a measure for therapy evaluation or treatment planning. In this study, the accuracy of PK parameters in brain DCE...
متن کامل